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The inter-alpha trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. ITI-H1 contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.
H1P; IATIH; IGHEP1; inter-alpha (globulin) inhibitor, H1 polypeptide; inter-alpha trypsin inhibitor, heavy chain 1; inter-alpha-inhibitor heavy chain 1; inter-alpha-trypsin inhibitor complex component III; inter-alpha-trypsin inhibitor heavy chain 1; inter-alpha-trypsin inhibitor heavy chain H1; Intin1; ITI heavy chain H1; ITIH; ITIH1; Itih-1; ITI-HC1; Serum-derived hyaluronan-associated protein; SHAP
100 µL
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